Lysosome Journal Articles 2006

Lysosome Journal Articles 2006

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Different expression of lysosome-associated membrane ...

    http://journals.lww.com/melanomaresearch/Abstract/2006/06000/Different_expression_of_lysosome_associated.5.aspx
    Lysosome-associated membrane protein-1 is a protein with a significant content of β1,6-branched N-glycans.It is thought that enhanced expression of lysosome-associated membrane protein-1 in tumour cells may promote invasion by influencing both adhesion to extracellular matrix and perhaps also binding to endothelial cells. The present study was aimed at examining levels of …

Lysosomes: fusion and function | Nature Reviews …

    https://www.nature.com/articles/nrm2217
    Cell 17, 4014–4026 (2006). Article CAS PubMed PubMed Central Google Scholar 21. Di Pietro, S. M. et al. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on ...

The Biogenesis of Lysosomes and Lysosome-Related …

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142962/
    Delivery to lysosomes. Lysosomes (L) are terminal compartments of the endocytic and autophagic pathways (AP). Newly synthesized lysosomal proteins are delivered to them from the trans-Golgi network (TGN) via early endosomes (EE), recycling endosomes (RE), and late endosomes/multivesicular bodies (LE/MVB).Following lysosome fusion with late endosomes …

Hypochlorous acid induces apoptosis of cultured cortical ...

    https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2006.03996.x
    Journal of Neurochemistry Free Access Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes Yann Wan Yap, Matthew Whiteman, Boon Huat Bay, Yuhong Li, Fwu-Shan Sheu, Robert Z. Qi, Chee Hong Tan, Nam Sang Cheung First published: 05 July 2006

Mechanisms and functions of lysosome positioning | …

    https://journals.biologists.com/jcs/article/129/23/4329/55610/Mechanisms-and-functions-of-lysosome-positioning
    Lysosomes have been classically considered terminal degradative organelles, but in recent years they have been found to participate in many other cellular processes, including killing of intracellular pathogens, antigen presentation, plasma membrane repair, cell adhesion and migration, tumor invasion and metastasis, apoptotic cell death, metabolic signaling and gene …

Presenilin 1 maintains lysosomal Ca2+ homeostasis by ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558203/
    PS1-dependent regulation of lysosomal pH is essential for lysosomal Ca 2+ homeostasis mediated by TRPML1. To investigate the relationship between defects in lysosomal Ca 2+ homeostasis and lysosomal acidification in PS1KO cells, we measured lysosomal Ca 2+ levels and observed lowered lysosomal Ca 2+ levels, as previously reported (Coen et al., 2012) …

(PDF) Lysosomes: Fusion and function - ResearchGate

    https://www.researchgate.net/publication/6200294_Lysosomes_Fusion_and_function
    Abstract. Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane-trafficking …

Early involvement of lysosome dysfunction in the ...

    https://onlinelibrary.wiley.com/doi/10.1111/jnc.13957
    Autophagy is a process in which damaged/aggregating proteins are transferred to lysosomes wherein they are degraded (Klionsky et al. 2016). Recent findings suggest that the autophagy–lysosome pathway is impaired in AD and PD (reviewed by Nixon 2013). Neurons may be particularly prone to impaired lysosomal degradation of autophagic substrates ...

Lysosomal cell death at a glance | Journal of Cell Science ...

    https://journals.biologists.com/jcs/article/126/9/1905/54333/Lysosomal-cell-death-at-a-glance
    Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases that can degrade most cellular macromolecules. Lysosomal membrane permeabilization and the consequent leakage of the lysosomal content into the cytosol leads to so-called “lysosomal cell death”. This form of cell death is mainly carried out by the ...

β-Coronaviruses Use Lysosomes for Egress Instead of …

    https://www.cell.com/cell/fulltext/S0092-8674(20)31446-X
    Ghosh et al. provide evidence that β-coronaviruses do not use the biosynthetic secretory pathway typically used by enveloped viruses to leave infected cells. Instead, these viruses traffic to lysosomes for unconventional egress by Arl8b-dependent lysosomal exocytosis. Their non-lytic release results in lysosome deacidification, inactivation of lysosomal …

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