Lateral Sclerosis Journal
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting primarily the motor system, but in which extra‐motor manifestations are increasingly recognized. The loss of upper and lower motor neurons in the motor cortex, the brain stem nuclei and the anterior horn of the spinal cord gives rise to progressive muscle weakness and wasting.
Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system. Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is clinical, after exclusion of structural, neurodegenerative and metabolic mimics. Differentiation of PLS from upper motor neuron-predominant forms of amyotrophic lateral sclerosis remains a …
Jaime Raymond, Paul Mehta, Ted Larson, Pam Factor-Litvak, Bryn Davis & Kevin Horton (2021) History of vigorous leisure-time physical activity and early onset amyotrophic lateral sclerosis (ALS), data from the national ALS registry: 2010–2018, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, DOI: 10.1080/21678421.2021.1910308.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 22, Issue sup2 (2021)
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration: Vol 22, No sup2 Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration publishes research into motor neuron diseases, covering all aspect of ALS and frontotemporal dementia. Submit an article New content alerts RSS
Amyotrophic lateral sclerosis (ALS) is a progressive, paralytic disorder characterized by degeneration of motor neurons in the brain and spinal cord.
Box 1. Amyotrophic lateral sclerosis (ALS) is a progressive and degenerative motor neuron disease. Motor neuron diseases occur along a spectrum with varying degrees of lower and upper motor neuron dysfunction. ALS is the most common motor neuron disease and affects both the lower and upper motor neurons.
"Lateral sclerosis" refers to hardening of the anterior and lateral corticospinal tracts as motor neurons in these areas degenerate and are replaced by gliosis . Despite advances in investigative medicine over the past century, the diagnosis of ALS is based on the presence of very characteristic clinical findings in conjunction with investigations to exclude "ALS-mimic" …
Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease," is a progressive motor neuron disease which leads to problems with muscle control and movement.   There are various types of ALS that are distinguished by symptoms and, in some cases, genetic cause. 
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